glyPAQ

glyPAQ is a workflow for simultaneous preparation of biological samples for structure-based glycan and proteomics analysis


Key Features:

  • glyPAQ enables quantitative MS-based glycan structure studies without requiring pre-purification of specific proteins or specialized expertise for sample preparation.

  • glyPAQ utilizes multiple internal standards for quality control of all sample handling steps and to normalize LC retention times and aid glycan structure assignment.

  • glyPAQ can be applied for routine glycomic profiling starting with just 1 μl serum or plasma, providing an innovative strategy to develop non-invasive biomarkers for precision medicine.

  • glyPAQ can be used to simultaneously prepare biological samples for structure-based glycomics and proteomics analysis.

glyPAQ has been licensed to ProtiFi, LLC.
Click here to visit their webpage and inquire about purchasing.

Wojtkiewicz M, Subramanian SP, Gundry RL, Multinozzle emitter for improved negative mode analysis of reduced native N-glycans by microflow porous graphitized carbon liquid chromatography mass spectrometry, Analytical Chemistry, 2024, in press.